Advances in research on intronic miRNAs feedback regulation of their host genes
- VernacularTitle:内含子miRNA反馈调节宿主基因的表达与功能研究进展
- Author:
Bao-Chun, HUANG
;
Guo-Jun, CAO
;
Ning-Sheng, SHAO
- Publication Type:Journal Article
- Keywords:
miRNA;
introns;
host gene;
feedback regulation
- From:Bulletin of The Academy of Military Medical Sciences
2009;33(6):580-582,595
- CountryChina
- Language:Chinese
-
Abstract:
miRNAs were discovered less than a decade ago, and have emerged as important regulators of gene expression in mammals. A large number of miRNAs have been identified to be located within the intronic regions of protein-encoding genes(host genes) and called intronic miRNAs. The intronic miRNAs may play a key role in regulating the expression and function of their host genes due to the fact that most of them are co-expressed with the host genes. In this paper, the recent advances on the research on potential relationship between intronic miRNAs and their host genes are reviewed.
