Synthesis and quality analysis of sodium 18 F-fluoroacetate and its precursor

VernacularTitle:18F-氟乙酸盐及其前体的合成和质量分析
Author: Hong-xia, LIU ; Ying-jian, ZHANG ; Yong-ping, ZHANG ; Ji-zhao, XIE ; Jun-yan, XU ; Zhi-feng, YAO ; Qing, ZHAO
Publication Type:Journal Article
Keywords: Acetates; Fluorine radioisotopes; Chemical synthesis
From:Chinese Journal of Nuclear Medicine 2011;31(4):259-262
CountryChina
Language:Chinese
Abstract: Objective To synthesize and analyze sodium 18F-fluoroacetate (FAC) and its precursor ethyl O-mesylglycolate (EOMG). Methods EOMG was synthesized using modified method. Its chemical purity was checked by HPLC and its structure was elucidated on the basis of spectral analyses. Final product of 18F-FAC was synthesized based on general nucleophilic reactions module Explora GN using EOMG as a precursor. Liquid chromatography Explora LC was applied to get rid of its chemical impurities.Then HPLC and radio-thin layer chromatography were used to assay its radiochemical purity, chemical purity and specific activity. Results EOMG was synthesized and identified. Its yield was 70% and its chemical purity was 97.0% (calculated by chromatographic peak area). The radiochemical purity of 18F-FAC was more than 98%, and its specific activity was 236. 5 MBq/μmol. Conclusion This synthetic method for 18F-FAC and its precursor can be defined as effective and highly quality-controlled.