Therapeutic potential and applications of blockade of CD40/CD40L interactions
- VernacularTitle:阻断CD40/CD40L相互作用的治疗潜力及应用前景
- Author:
HeZhong, LIU
- Publication Type:Journal Article
- From:Bulletin of The Academy of Military Medical Sciences
2001;25(2):143-147
- CountryChina
- Language:Chinese
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Abstract:
T cell plays a pivotal role in immune system. Not only direct antigen stimulation, but also costimulation signal transducted through cell/cell membrane molecule interactions are needed in the procedure of T cell activation. Besides B7/CD28, CD40/CD40L signal is another important costimulatory pathway, and plays critical roles in many physiologic processes. The disorders of CD40/CD40L costimulatory pathway always lead to serious pathologic phenomena. In this article, the role of CD40/CD40L interactions and therapeutic potentials of blockade of it are discussed.
