18F-FDG PET/CT associated with MRI in epilepsy surgery
10.3760/cma.j.issn.0253-9780.2010.06.005
- VernacularTitle:18F-FDG PET/CT结合MRI在癫(癎)外科治疗中的应用
- Author:
Xu, CHEN
;
Kai, SHU
;
Ting, LEI
;
Qing, JIA
;
Ling, LI
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Surgery,operative;
Tomography,emission-computed;
Tomography,X-ray computed;
Magnetic resonance imaging;
Deoxyglucose
- From:Chinese Journal of Nuclear Medicine
2010;30(6):372-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate retrospectively the role of 18 F-fluorodeoxyglucose (FDG) PET/CT associated with MRI in the localization of epileptogenic foci. Methods Sixty-seven patients with medically resistant epilepsy were included from 2003 to 2008. All underwent 18F-FDG PET/CT and MRI for presurgical evaluation as well as post-surgical evaluation 12 to 65 months after operation. Based on postoperative seizure occurrence, patients were divided into two groups. One group was free of seizures ( Engel classification Ⅰ, Group 1) and the other was with postoperative seizure occurrence of any type ( Engel classification Ⅱ-Ⅳ, Group 2). X2-test or Fisher's exact test was used for the statistical analysis. Results About 71.6% (48/67) patients were defined as group 1, and 19 patients were group 2 ( 11 were Engel Ⅱ , 5 were Engel Ⅲ, and 3 were Engel Ⅳ ). In Group 1, no statistically significant difference was found between concordant (45/63) and discordant findings (3/4) with regard to 18F-FDG PET/CT and MRI images (Fisher's exact test, P ＞0.05). For 41 patients that showed focal abnormality both on MRI and 18F-FDG PET/CT, 80.5% (33/41) were found in group 1. For 20 patients that showed focal lesions on MRI while with multi-focal or generalized abnormal metabolism on 18F-FDG PET/CT, 11 (55.0%) were in group 1 and9 (45.0%) were group 2. There was no significant difference (33/41 vs 11/20, X2 =4.34, P ＜0.05 ). Conclusion 18F-FDG PET/CT associated with MRI may offer more helpful information for pre-surgical evaluation and prediction of prognosis of epileptic patients.
