The study of ictal brain SPECT during seizures induced by clonidine and sleep-deprivation in patients with epilepsy
10.3760/cma.j.issn.0253-9780.2010.06.006
- VernacularTitle:可乐定联合剥夺睡眠诱发癫(癎)发作的SPECT脑血流灌注显像研究
- Author:
Xiao-hui, WANG
;
Xue-hong, CHEN
;
Zheng-jiang, WANG
;
Jiang-yan, LIU
;
Jian-zhong, FENG
;
Jiang, YE
;
Li, ZHAO
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Sleep deprivation;
Clonidine;
Tomography,emission-computed,single-photon;
ECD
- From:Chinese Journal of Nuclear Medicine
2010;30(6):375-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility and clinical value of combined clonidine and sleep-deprivation induced seizures for ictal brain SPECT imaging in patients with epilepsy. Methods Fiftytwo epilepsy patients were given oral clonidine plus sleep-deprivation to induce seizures with video-electroencephalogram (VEEG) monitoring. Forty-seven patients were selected as control group, whose seizures were induced by sleep-deprivation only. 99Tcm-ethylcysteinate dimer (ECD) was injected within 30 s since a clinical sign and/or a typical EEG discharge of epilepsy was recognized. Brain SPECT was performed 30 min after 99TcmECD injection. X2-test was performed by using software SPSS 10. 0. Results One to two hrs after oral intake of clonidine plus sleep-deprivation, 75% (39/52) patients were induced seizures, including 92.3% (36/39) with subclinical seizures and 7.7% (3/39) with clinical seizures. Ictal brain SPECT localized the lesions with high uptake of 99Tcm-ECD in 37 (94.9%) patients. In control group, 38.3% ( 18/47) were induced epileptic seizures, including 77.8% (14/18) with subclinical seizures and 22.2% (4/18) with clinical seizures. The induction rate of epileptic seizures in clonidine plus sleep-deprivation group was significantly higher than that of control group (X2 = 13.614, P ＜ 0.01 ). However, there was no significant difference in clinical seizures between the two groups (X2 = 1.253, P ＞ 0.05 ). Conclusions The combination of oral intake of clonidine and sleep-deprivation could increase the induction rate of epileptic seizures and it is effective for epilepsy SPECT imaging.
