Progress in monoclonal antibody humanization based on complementarity-determining region grafting
- VernacularTitle:基于互补决定区移植的单抗人源化进展
- Author:
xiao-lin, ZHU
;
feng, CHENG
;
guan-xiang, QIAN
- Publication Type:Journal Article
- Keywords:
complementarity-determining region;
graft;
humanization;
antibody;
immunogenicity
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Humanized monoclonal antibodies(mAbs) are increasingly widely used in targeted therapy for cancer and some other major diseases.Complementarity-determining region(CDR) grafting makes quantities of humanized mAbs available.Herein,we provide an overview on the strategy and progress of CDR grafting.
