Research advances on inducing bone marrow stromal cells chondrogenic differentiation in vitro
- VernacularTitle:骨髓基质干细胞体外软骨定向诱导方法的研究进展
- Author:
xia, LIU
;
guang-dong, ZHOU
;
yi-lin, CAO
- Publication Type:Journal Article
- Keywords:
bone marrow stromal cells;
chondrogenic differentiation;
tissue engineering
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The source of seed cells has always been the major problem in cartilage tissue engineering.Bone marrow stromal cells (BMSCs) have gradually become an optimal source of seed cells for cartilage engineering due to their high proliferative potential,multi-lineage differentiation potential and easiness to be obtained with minute trauma.The great challenge is how to get abundant BMSCs with a high purity and how to induce them in vitro into chondrogenic phenotype.This review aims to discuss the various strategies that can induce BMSCs chondrogenic differentiation in vitro so as to offer beneficial reference for constructing cartilage with BMSCs as seed cells.
