Research Advances on the Relationship Between Hyperhomocysteinemia and Obstructive Vascular Disease
- VernacularTitle:高同型半胱氨酸血症与血管阻塞性疾病相关性研究进展
- Author:
fang, WANG
;
rui, XI
;
guo-ping, LU
- Publication Type:Journal Article
- Keywords:
homocysteine;
hyperhomocysteinemia;
atherosclerosis;
thrombosis
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Hyperhomocysteinemia is an independent risk factor for arterial and venous obstructive vascular di-seases. Raised plasma homocysteine concentrations are caused by genetic and non-genetic factors. The pathogenic mechanism is not clear. It may be associated with endothelium dysfunction, abnormal lipid metabolism, hypertrophy of intima media, increased platelet aggregation and several clotting factors interfered, etc. The metabolism and pathogenic mechanism of homocysteine are reviewed in this article, which provides theoretical foundation for the treatement of hyperhomocysteinemia.
