Oxaliplatin Induced Neurotoxicity: Characteristic and Therapy
- VernacularTitle:奥沙利铂的神经毒性和防治进展
- Author:
qian, LI
;
wei-jian, GUO
;
lei-zhen, ZHENG
- Publication Type:Journal Article
- Keywords:
oxaliplatin;
neurotoxicity;
side effect
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Oxaliplatin, the third generation of the platinum based chemotherapy agent, is effective in the treatment of multiple solid tumors and is also quite safe. However, there is a high incidence of peripheral neurotoxiciy, which is dose-limiting. Oxaliplatin induces two distinct forms of neurotoxicity: an acute syndrome that is triggered or aggravated by exposure to cold, and chronic cumulative sensory neurotoxicity which in nature resembles characteristics of cisplatin associated neurotoxicity. In this article, the clinical manifestations, electrophysiologic abnormalities, mechanism of neurotoxicity and therapy are reviewed.
