Clinical study on intravitreal injection of cannabinoid HU - 211 for optic nerve damage in glaucoma rats
10.3980/j.issn.1672-5123.2014.09.06
- VernacularTitle:玻璃体腔注射大麻素 HU-211治疗鼠青光眼视神经损伤的研究
- Author:
Hui-Feng, LIU
;
Yuan, HE
;
Jun, JIA
;
Ming-Li, JI
;
Jin-Wei, XI
- Publication Type:Journal Article
- Keywords:
cannabinoid HU - 211;
glaucoma;
optic nerve protective
- From:
International Eye Science
2014;(9):1584-1586
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the protective effects of intravitreal injection of cannabinoid HU - 211 for optic nerve in glaucoma rats, providing the experimental evidence in the treatment of glaucoma optic nerve injury.
●METHODS: Glaucoma rats (18 eyes) were modeled by electric coagulation sclera surface vein and randomized into 3 groups, group A received intravitreal injection of 1mg/ 0. 1mL cannabinoid HU - 211 every other day respectively; group B was given intravitreal injection of 0. 1mL water every other day, group C was high intraocular pressure (lOP) group, 6 eyes were randomly selected for blank control group ( group D). lOP was observed every day. The rats were sacrificed after treatment 4wk, froze retina section, HE stain. The density fluctuation of retinal ganglion cell ( RGC ) neurons assessment the optic nerve of rat model with chronic high lOP glaucoma were measured.
●RESULTS: The apoptosis and damage degree of RGC in group B was obviously higher than that in group A, with statistically significant difference (P<0. 05). There was no significant difference in groups B and C (P >0. 05).
●CONCLUSlON: lntravitreal injection of cannabinoid HU-211 shows obvious protective effect on optic nerve in glaucom rat models.
