Expression of vascular endothelial cell growth factor and its receptors in vitreous of patients with diabetic retinopathy
10.3980/j.issn.1672-5123.2014.09.07
- VernacularTitle:血管内皮生长因子及其受体在 DR 患者玻璃体中的表达
- Author:
Huan-Lian, LI
;
Jin-Wen, ZHOU
;
Wei, ZUO
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
vascular endothelial cell growth factor;
Flt-1;
KDR
- From:
International Eye Science
2014;(9):1587-1589
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of vascular endothelial cell growth factor (VEGF) and its receptors in vitreous of patients with diabetic retinopathy ( DR), and to discuss its role in the development of DR.
●METHODS: Selected 13 patients (16 eyes) with DR and 15 healthy people (15 eyes), the expression of VEGF and its receptors (fms-like tyrosine kinase-1, Flt-1 and kinase insert domain containing receptor, KDR) were evaluated by immunohistochemistry in vitreous. The levels of VEGF, the Flt-1 and KDR in vitreous of patients with DR were examined with enzyme linked immunosorbent assay (ELlSA).
● RESULTS: lmmunohistochemical staining showed that the expression of VEGF, Flt-1 and KDR in vitreous vessel membrane of patients with DR was increased significantly. And the levels of VEGF, Flt - 1 and KDR in vitreous of patients with DR were obviously higher than that in the control group (P<0. 05 or P<0. 01).
● CONCLUSlON: VEGF, Flt - 1 and KDR were widely expressed in vitreous of patients with DR, and were positively related to micro-angiogenesis of DR patients. lt proved that VEGF and its receptors played important roles in the occurrence and development of DR.
