Systematic reviews of ganciclovir versus acyclovir for herpes simplex virus keratitis
10.3980/j.issn.1672-5123.2014.09.08
- VernacularTitle:更昔洛韦对比阿昔洛韦治疗单纯疱疹病毒性角膜炎的系统评价
- Author:
Jing-Yuan, LI
;
Shu-Qin, LI
- Publication Type:Journal Article
- Keywords:
ganciclovir;
acyclovir;
herpes simplex virus keratitis;
systematic reviews
- From:
International Eye Science
2014;(9):1590-1593
- CountryChina
- Language:Chinese
-
Abstract:
To assess the efficiency and reliability safety of ganciclovir to herpes simplex virus keratitis.
●METHODS: All of the randomized controlled trials for the study of ganciclovir versus acyclovir in the treatment of herpes simplex virus keratitis were collected from Cochrane Library, EMbase, PubMed, Chinese Bio -medicine Database, China Journal Full-text Database, VlP Database and WanFang Database. Then the data were extracted and evaluated by two reviewers independently. Risk of bias assessment was evaluated by a tool recommended by Cochrane Library. Revman 5. 0 software was used for statistical analysis.
●RESULTS: Finally, 14 randomized controlled trials were included, 4820 patients totally. Subgroups were used according to the number of patients and diseased eyes as well as the difference of follow-up time. For and relapse rate, ganciclovir group was overmatch acyclovir group. There were statistical differences between the two groups [RR= 1. 22, 95%CI (1. 10-1. 36); OR = 4. 50, 95% CI (2. 02-10. 04); RR = 0. 23, 95% CI (0. 10-0. 52)]. Compared with acyclovir, ganciclovir had less side - effect. There were statistical differences between the two groups [RR = 0. 12, 95%CI (0. 03 - 0. 46)]. All of the side effects of the two groups can be relieved by themselves.
● CONCLUSlON: Current evidence suggests that the ganciclovir is more efficient and safe than acyclovir in the treatment of herpes simplex virus keratitis.
