Effects of applying trichostatin A on filtration bleb after filtering surgery in rabbits

VernacularTitle:曲古抑菌素A对兔眼滤过术后滤过泡作用的研究
Author: Xiao-Yan, LI ; Ying, DENG ; Jian-Gang, YANG
Publication Type:Journal Article
Keywords: histone deacetylase inhibitor; trichostatin A; filtration surgery; filtration bleb; mitomycin C
From: International Eye Science 2014;(10):1776-1778
CountryChina
Language:Chinese
Abstract: AIM: To observe the morphologic changes of of filtration blebs after trichostatin A treatment in an experimental glaucoma filtration surgery ( GFS) .
METHODS:Subconjunctival injection TSA, mitomycin C ( MMC) and PBS during the filtering surgery in rabbits. The morphologic changes of filtration blebs were evaluated by Krofeld score method postoperatively days 3, 7, 14, 21, and 28.
RESULTS: TSA induced filteation bleds were elevated diffusely within 14d and cystic blebs formed 28d, filtration bleb score was significantly higher in TSA group than that in PBS group.
CONCLUSION: TSA can keep the aqueous humor outflow by inhibiting scar formation and prolong the existence of the filtration bleb.