Clinical study on botulinum toxin A injections for blepharospasm

VernacularTitle:A型肉毒毒素治疗眼睑痉挛的临床研究
Author: Yong-Hong, JIAO ; Yi-Di, WANG ; Zhe, PAN
Publication Type:Journal Article
Keywords: botulinum toxin A; local injection; blepharospasm
From: International Eye Science 2014;(7):1350-1351
CountryChina
Language:Chinese
Abstract: AlM:To observe the efficacy of using botulinum toxin A in the treatment of blepharospasm.
METHODS: Totally 113 patients with blepharospasm were managed with a local injection of botulinum toxin A, and the therapeutic effect was evaluated.
RESULTS:Fifty-nine cases ( 52. 2%) had a complete remission of symptoms, 49 patients ( 43. 4%) presented with obvious relieved spasm, 4 cases ( 3. 5%) were partially relieved and the 1 patient ( 0. 9%) remained unchanged. The total effective rate was 99. 1%. The time of beginning effect was 1-14d. The recover time was mostly in 14d. The average of therapeutic effect lasted 1-9mo. Adverse reactions such as mild palpebra dysraphism, palpebra ptosis and local subcutaneous blood stasis were found in 23 patients, and the symptoms disappeared in 2-4wk.
CONCLUSlON:Botulinum toxin A can effectively control medium and severe blepharospasm by injecting a little dose on local muscle.