Clinical research of protein-free calf blood extract eye gel for corneal epithelial defect
10.3980/j.issn.1672-5123.2014.07.39
- VernacularTitle:小牛血去蛋白眼用凝胶治疗角膜上皮缺损的临床观察
- Author:
Xiao-Xia, NIU
;
Yun-Feng, LI
;
Lu-Yang, ZHAN
- Publication Type:Journal Article
- Keywords:
protein-free calf blood extract eye gel;
basic fibroblast growth factor eye gel;
corneal epithelial defect
- From:
International Eye Science
2014;(7):1313-1315
- CountryChina
- Language:Chinese
-
Abstract:
AlM: To evaluate the clinical effect of 200g/L protein-free calf blood extract eye gel for corneal epithelial defect.METHODS: One hundred and sixty - eight cases of corneal epithelial defect ( 58 cases with herpes simplex keratitis; 24 cases with chemical injury; 85 cases with pterygium operation injury ) were randomly divided into two groups: 84 eyes were treated with protein-free calf blood extract eye gel; 84 cases were treated with basic fibroblast growth factor eye gel ( bFGF ) . The bFGF and protein-free calf blood extract eye gels were used 4 times a day. The treatment course was 7d. Epithelial defect restoration, local symptom and sign were observed.
RESULTS: The difference between pre-treatment and post-treatment was significant ( P<0. 01 ) in the two groups. The effect of protein-free calf blood extract eye gel (83. 3%) group was prior to that of bFGF (69%) for corneal epithelial defect. The effective rate of protein-free calf blood extract eye gel in the herpes simplex keratitis, chemical injury and pterygium operation injury was 72. 4%,69. 2% and 95. 2%. Localized stimulus and adverse reaction of all over the body were not been observed.
CONCLUSlON: Protein-free calf blood extract eye gels is valuable and safe for corneal epithelial defect.
