Expressions and clinical significance of PDCD4 and B7 - H4 in optic gliomas in children
10.3980/j.issn.1672-5123.2014.08.06
- VernacularTitle:PDCD4和B7-H4在儿童视神经胶质瘤中的表达及临床意义
- Author:
Yan-Tong, LIU
- Publication Type:Journal Article
- Keywords:
children;
optic;
gliomas;
PDCD4;
B7-H4
- From:
International Eye Science
2014;(8):1391-1393
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expressions and clinical significance of PDCD4 and B7-H4 in optic gliomas in children.
METHODS:We used immunohistochemistry to evaluate the expressions of PDCD4 and B7-H4 in specimens from 52 optic gliomas in children cases, and analyzed the correlation of PDCD4 and B7 - H4 expression with clinicopathological factors children optic gliomas.
RESULTS: PDCD4 expression reduced in optic glioma tissue:PDCD4 expression rate in 52 cases of optic glioma tissues decreasing was correlated with tumor malignancy increase (P<0. 01); B7-H4 positive expression increased in optic glioma tissue: B7-H4 expression rate in 52 cases of optic glioma tissues increasing was correlated with tumor malignancy increase (P<0. 01); PDCD4 expression was negatively correlated with B7-H4 expression in optic gliomas (P<0. 01).
CONCLUSION: Expressions of PDCD4 and B7-H4 may be clinically relevant to tumor malignancy of optic gliomas in children and prevention of metastasis and prediction of prognosis.
