Research process of mTOR pathway in proliferative - relatively diseases in ophthalmology
10.3980/j.issn.1672-5123.2014.08.13
- VernacularTitle:mTOR通路在眼科增殖相关性疾病中的研究进展
- Author:
Yi-Han, WANG
;
Lin, LIU
- Publication Type:Journal Article
- Keywords:
mTOR pathway;
posterior capsule opacification;
proliferative vitreoretinopathy;
proliferative diseases
- From:
International Eye Science
2014;(8):1417-1419
- CountryChina
- Language:Chinese
-
Abstract:
The mammalian TOR ( mTOR ) pathway is a key regulator of cell growth and proliferation which is also a fundamentally important player in a large variety of human diseases. The pathway regulates many key cellular processes and is implicated in a large number of pathological conditions, including cancer, obesity, diabetes, and cardiovascular disease, age - related diseases and other proliferative disease. It integrates signals from nutrients, energy status and growth factors to regulate many processes, including autophagy, ribosome biogenesis and metabolism. Our article reviews the advancement of laboratory results on mTOR pathway in proliferative diseases in ophthalmology.
