TGF - β1 and HSP - 47 expression in pterygium
10.3980/j.issn.1672-5123.2014.07.06
- VernacularTitle:TGF-β1和HSP-47在翼状胬肉中的表达及其意义
- Author:
Hui, YAN
;
Ru-Gang, PAN
;
Sha-Sha, YAO
;
Zhi-Rong, YANG
- Publication Type:Journal Article
- Keywords:
pterygium;
TGF-β1;
HSP-47
- From:
International Eye Science
2014;(7):1203-1205
- CountryChina
- Language:Chinese
-
Abstract:
AlM:To investigate the expression transforming growth factor-β1 (TGF-β1) and heat shock protein 47 (HSP-47), in pterygium and normal conjunctiva tissues, in order to study the roles of these cytokines played in the pathogenesis in human pterygium.
METHODS:The expression difference of TGF-β1, HSP-47 between human pterygium and normal conjunctive tissues were compared by immuno - histochemistry technique.
RESULTS:The positive expression of TGF-β1, HSP-47 was stronger than in normal conjunctive tissues ( P <0. 05), the TGF-β1 expressed in all layers of pterygium, especially in the squamous epithelium, in the inflammation cells and vascular endothelial cells also expressed. The HSP-47 showed higher expressed in the lamina propria layer of pterygium, and weakly expressed in epithelial layer, no obvious expression in normal conjunctive tissues.
CONCLUSlON:Over-expression of TGF-β1 and HSP-47 in pterygium compared to the normal conjunctiva tissues may play a critical role during the occurrence, development and invasion of the pterygium.
