Preliminary Suggestion about Staging of Anorectal Malignant Melanoma May Be Used to Predict Prognosis.
- Author:
Won Young CHAE
1
;
Jong Lyul LEE
;
Dong Hyung CHO
;
Chang Sik YU
;
Jin ROH
;
Jin Cheon KIM
Author Information
- Publication Type:Original Article
- Keywords: Anus canal; Rectum; Melanoma; Neoplasm staging
- MeSH: Disease-Free Survival; Humans; Lymph Nodes; Melanoma*; Neoplasm Metastasis; Neoplasm Staging; Prognosis*; Rectum; Retrospective Studies
- From:Cancer Research and Treatment 2016;48(1):240-249
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Anorectal malignant melanomas (AMM) are rare and have poor survival. The study aims to evaluate the clinicopathologic characteristics and outcomes of patients with AMM, and to devise a staging system predictive of survival outcome. MATERIALS AND METHODS: This was a retrospective study of 28 patients diagnosed with, and treated for AMM. Patients classified by clinical staging of mucosal melanoma (MM) were reclassified via rectal and anal TNM staging. Survival outcomes were compared among patients grouped by the three different staging systems. RESULTS: The three staging systems were equated with similar figures for 5-year overall survival (OS) and 5-year disease-free survival (DFS) of patients diagnosed with stage I disease. Patients (n=19) diagnosed with MM stage II disease were reclassified by rectal TNM staging into three subgroups: IIIA, IIIB, and IIIC. For these patients, both 5-year OS and 5-year DFS differed significantly between the subgroups IIIA and IIIC (OS: IIIA vs. IIIC, 66.7% vs. 0%, p=0.002; DFS: IIIA vs. IIIC, 51.4% vs. 0%, p < 0.001). CONCLUSION: The accuracy of prognosis in patients diagnosed with AMM and lymph node metastasis has improved by using rectal TNM staging, which includes information regarding the number of lymph node metastases.
