Lack of association between the TIGR gene mutation and the high myopia in Chinese children
10.3969/j.issn.1672-5123.2011.02.04
- VernacularTitle:高度近视儿童中未检测到TIGR基因突变
- Author:
Ping, WANG
;
Zhi-Chun, YE
;
Li-Juan, TAO
;
Xi-Rong, GAO
;
Li-Hua, XIE
;
Hui-Ling, YANG
;
Xi-Lang, WANG
- Publication Type:Journal Article
- Keywords:
high myopia;
open angle glaucoma;
mutation;
genes;
gene sequence
- From:
International Eye Science
2011;11(2):210-213
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To screen TIGR/myocilin gene (MYOC) mutation in high myopic Chinese children with family history.METHODS: Gene sequencing was performed in exon 3 of the TIGR gene in high myopic Chinese Children. The coding sequence of TIGR exon 3 was screened by capillary electrophoresis sequencing. The sequence alterations were analyzed by bioinformatics.RESULTS: TIGR gene mutation was not found in high myopic patients and normal controls group.CONCLUSION: No identified gene mutation is found in TIGR gene in high myopic Chinese children.
