A Clinicopathological Review of Pulmonary Metastasis from Uterine Cervical Cancer.
- Author:
Eun Young KI
1
;
Keun Ho LEE
;
Jong Sup PARK
;
Soo Young HUR
Author Information
- Publication Type:Original Article
- Keywords: Uterine cervical neoplasms; Pulmonary metastasis; Prognosis
- MeSH: Drug Therapy; Humans; Hysterectomy; Lung; Medical Records; Neoplasm Metastasis*; Prevalence; Prognosis; Uterine Cervical Neoplasms*
- From:Cancer Research and Treatment 2016;48(1):266-272
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of this study was to investigate the clinicopathological features of pulmonary metastasis from cervical cancer. MATERIALS AND METHODS: We reviewed the medical records of 56 patients with cervical cancer who developed pulmonary metastasis after radical hysterectomy, postoperative concurrent chemoradiation or systemic chemotherapy between January 1990 and March 2014. RESULTS: Fifty-six patients were diagnosed with pulmonary metastasis from cervical cancer. The prevalence of pulmonary metastasis was 3.6%. The mean event-free duration was 12 months. Twelve patients underwent surgical removal of metastatic lesions. The overall survival (OS) of patients with < or = 3 metastatic lung lesions was 40.7 months, longer than those with > 4 lesions (25 months, p=0.034). The OS of patients who underwent surgical resection was 53.8 months, longer than that of those who did not (p=0.006). In addition, the OS of patients with adjuvant platinum-based chemotherapy was 32.6 months (p=0.027). CONCLUSION: In this study, we found that the number of metastatic nodules, surgical resection, and postoperative platinum-based chemotherapy can influence clinical outcome. Further studies on prognostic factors and successful treatment modalities are warranted.
