Cyclin dependent kinase inhibitor P27, P21 expressions in human corneal epithelium
- VernacularTitle:细胞周期依赖性激酶抑制剂P27,P21在人角膜上皮的表达研究
- Author:
Ming-Chang, ZHANG
;
Hong-Xu, ZHANG
- Publication Type:Journal Article
- Keywords:
cyclin dependent kinase inhibitor;
P27;
P21;
proliferating cell nuclear antigen;
corneal epithelial stem cells
- From:
International Eye Science
2006;6(4):745-747
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expressions of the cyclin dependent kinase inhibitor (CKI) in human corneal epithelium.METHODS: The expressions of CKI, P27, P21 and proliferating cell nuclear antigen (PCNA) were tested in different regions of corneal epithelium by SP immunohistochemistry.RESULTS: Limbal basal cells stained positively for PCNA while central corneal epithelium cells stained negatively for PCNA, their difference was statistically significant (P＜0.01).Positive staining for P27 and P21 were observed in central epithelium, but there was no positive staining in limbal epithelium. Their difference were also statistically significant (P＜0.01).CONCLUSION: The different expressions of CKI P27, P21and PCNA in different corneal epithelial regions suggest that in limbal basal layer there are a group of cells that have higher proliferative capacity staying in G1 status, namely stem cell.
