Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model
- VernacularTitle:Ets-1在链脲左菌素诱导的糖尿病大鼠模型视网膜内表达增强
- Author:
Zhao-Jiang, DU
;
Peng, LI
;
Yan-Nian, HUI
;
Bai-Ren, WANG
;
Xiao-Li, DUAN
;
Rui, ZHANG
- Publication Type:Journal Article
- Keywords:
Ets-1;
VEGF;
diabetic retina;
angiogenesis
- From:
International Eye Science
2007;7(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine the involvement of Ets-1 in the pathological progress of the experimental diabetic retina. METHODS: Diabetes was induced by intraperitoneal injection of STZ. Total RNA and Total proteins were isolated from retinas of experimental and control eyes at 4 weeks after STZ-injection and were assessed by Northern blot analysis and Western blot analysis, respectively.RESULTS: Expression of both Ets-1 mRNA and Ets-1 protein was significantly increased in the experimental diabetic rat's retina after STZ-injection compared with the control group (P＜0.001).CONCLUSION: Our results indicated that Ets-1 was involved in the pathological progress of experimental diabetic retina.Further studies should be conducted to focus on the relationship between Ets-1 and VEGF in the diabetic retina.
