High myopia associated with colour vision deficiency:a family report
- VernacularTitle:高度近视伴色觉缺失的家系分析
- Author:
Nimet (U)nay GÜNDOGAN
;
Ay(s)e Gül Ko(c)ak ALTINTA(S)
;
Nezih DURMAZLAR
;
Koray, GÜMÜS
;
Zerrin YILMAZ
;
Kemal K(O)SEMEHMETO(G)LU
- Publication Type:Journal Article
- Keywords:
high myopia;
colour vision deficiency;
congenital colour blindness
- From:
International Eye Science
2007;7(3):602-608
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate genetic characteristics and clinical findings in a family with high myopia and colour vision deficiency (CVD).METHOD: Eight affected subjects of 42 members in four generations of the same family underwent a complete ophthalmic examination. Classical and computer adapted Ishihara Plates and Farnsworth-Munsell 100 Hue (FM100H)tests were used for determining the red-green CVD and full-field electroretinography (ERG) was performed to evaluate retinal function.RESULTS: Eight affected subjects had subnormal visual acuity due to high myopia. The results of colour vision tests were consistent with red-green CVD in six of these affected subjects. Fundus examination showed degenerative myopic changes characterized with generalized chorioretinal atrophy.Abnormal cone and rod dark-adaptation and diminished cone response in ERG were found in two subjects. According to family pedigree, it has been suggested that red-green CVD has X-linked recessive inheritance.CONCLUSION: The concurrence of high myopia with CVD in the members of this family may show a possible evidence for an associate genetic basis on different disorders.
