Inhibitory effects of pioglitazone on alkaline burninduced corneal neovascularization in rats
- VernacularTitle:吡格列酮对鼠角膜碱烧伤后新生血管抑制作用的研究
- Author:
Yi-Xia, ZHANG
;
Ming-Chang, ZHANG
- Publication Type:Journal Article
- Keywords:
pioglitazone;
CNV;
VEGF;
b-FGF
- From:
International Eye Science
2007;7(5):1202-1205
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of pioglitazone on corneal neovascularization(CNV)induced by alkali burnin rats and on expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF).METHODS: CNV was induced by alkaline burn in rats which were then administered pioglitazone subconjunctivally.Corneal angiogenesis was evaluated and observed with a slit lamp microscope and the VEGF and b-FGF level were determined by immunohistochemistry and Western blot at different intervals.RESULTS: The CNV of the rats was shown two days after alkaline burn, and reached its highest level in 7-10 days. The mean values of the area and length of neovascularization and the VEGF and b-FGF levels in the pioglitazone-treated group were significantly lower than those in the control group at various time.CONCLUSTON: Local application of pioglitazone could remarkably inhibit CNV, probably by means of downregulation of VEGF and b-FGF expression.
