Heme oxygenase-1 and diabetic retinopathy:role of oxidative stress
- VernacularTitle:血红素氧合酶-1与糖尿病性视网膜病变:氧化应激的作用
- Author:
Jun, WANG
;
Ming-Ming, YANG
;
Yan, TENG
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
oxidative stress;
heme oxygenase-1
- From:
International Eye Science
2008;8(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy is one of the most common and serious microvascular complications of diabetes, and it is a very complex pathological process, displaying multi-factor, multi-stage characteristic in the outcome. Recent studies have shown that the pathogenesis of diabetic retinopathy is closely related to oxidative stress, and antioxidant therapy can effectively improve the condition. Heme oxygenase-1(HO-1)is a widely existing antioxidant defense enzyme, which can reduce the injury caused by oxidative stress and plays an important physiological role. Studies have indicated that in retina HO-1 can be highly induced by hyperglycemia. Moreover, the expression level of HO-1 by man-made changes can accelerate or postpone the diseases progression. That means HO-1 for the diagnosis and treatment of diabetic retinopathy has satisfactory applied foreground. In this article we would like to review the role of HO-1 in diabetic retinopathy.
