Effects of enantiomers(R,R)-XY and(S,S)-XY on ocular blood flow in rabbits
- VernacularTitle:异构体(R,R)-XY和(S,S)-XY对兔眼血流的影响
- Author:
Jie, PENG
;
Yan-Hong, ZOU
;
Wei, JIANG
;
Xiao-Bin, JI
;
Xin-Yu, CHEN
;
Yi-Hua, ZHANG
;
Si-Xun, PENG
;
George C Y CHIOU
- Publication Type:Journal Article
- Keywords:
ocular blood flow;
ischemia;
enantiomer
- From:
International Eye Science
2008;8(3):437-441
- CountryChina
- Language:Chinese
-
Abstract:
·AIM: To evaluate the effects of two series of enantiomers [(R, R)-XY-1 through (R, R)-XY-12 and (S,S)-XY-1 through (S, S)-XY-12] on ocular blood flow in rabbits.·METHODS; Colored microsphere technique was used for in vivo experiments to determine the ocular blood flow in various tissues of ocular hypertensive (40mmHg) rabbit eyes.·RESULTS; Of the twelve compounds of ( R, R)-XY series examined, four increased choroidal blood flow at 10g/L, 50uL instilled into eyes. All compounds of (S, S)-XY series were not effective on ocular blood flow.·CONCLUSION; Some compounds of (R, R)-XY series increased the ocular blood flow, which might be useful for the prevention and treatment of ocular blood flow related eye diseases. Among all twenty-four compounds, (R, R)-XY-1and (R, R)-XY-9 seem to be the most potent ones.KEYWORDS; ocular blood flow; ischemia; enantiomer
