Immunodepression during experimental Naegleria meningoencephalitis in mice.
10.3347/kjp.1987.25.2.195
- Author:
Kyung Il IM
1
;
Jae Sook RYU
;
Keun Tae LEE
Author Information
1. Department of Parasitology, College of Medicine and Institute of Tropical Medicine, Yonsei University, Seoul 120, Korea.
- Publication Type:Original Article
- MeSH:
parasitology-protozoa;
Naegleria fowleri;
meningoencephalitis;
immunology;
T-cell;
B-cell;
brain
- From:The Korean Journal of Parasitology
1987;25(2):195-198
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to test the function of lymphocytes in Naegleria fowleri-infected mice, the in vitro blastogenic response of splenocyte cultures to non-specific mitogens was studied. Concanavalin A and lipopolysaccharide stimulation were used as tests of T cell and B cell function. For the first 14 days following N. fowleri infection, lymphoblastic transformation induced by T-cell mitogen was markedly reduced in comparison to the uninfected control mice. The blastogenic response to B-cell mitogen remained depressed in the infected mice up to 14 days after infection. The fluorescent antibody titers of sera of N. fowleri infected mice were between 1:4 and 1:32. The results suggest that there is a suppression of cell mediated immunity during the acute course of experimental Naegleria meningoencephalitis in mice.
