Duane's retraction syndrome and karyotypic abnormalities
- VernacularTitle:杜安眼球后退综合征和染色体组异常
- Author:
Alireza K-JAFARI
;
Seyed-Masoud HOSHMAND
;
Iraj AHADZADEGHAN
;
Faramarz ANVARI
;
Abroad AMERI
;
Mohammad-Reza AKBARI
;
Mohammad Taher RAJABI
- Publication Type:Journal Article
- Keywords:
Duane's retraction syndrome(DRS);
polymerase china reaction(PCR);
chromosome
- From:
International Eye Science
2008;8(9):1747-1748
- CountryChina
- Language:Chinese
-
Abstract:
AIM:TO evaluate chromosome 8 abnormalities in Duane's retraction syndrome(DRS)type 1.METHODS:We evaluated chromosome 8 abnormalities in 29 consecutive cases of DRS type Ⅰ.DNA was isolated from the peripheral leukocytes of patients using a genomic DNA extraction kit,then D8S553 and D8S1797 markers used for polymerase chain reaction(PCR).RESULTS:None of the cases were positive for the two markers D8S553 and D8S1797 on chromosome 8 which were tested in our study.CONCLUSION:The possible cause of this finding is that DRS in our patients is more commonly sporadic rather than familial.We recommend study with more cases,other markers,and different chromosomes.
