Effects of naringenin on ocular blood flow and choroidal neovascularization in experimental animals
10.3969/j.issn.1672-5123.2009.01.001
- VernacularTitle:柚皮素对大鼠眼血流和脉络膜新生血管的作用
- Author:
Jie, JI
;
Xin-Rong, XU
;
George C Y CHIOU
- Publication Type:Journal Article
- Keywords:
naringenin;
choroidal neovascularization;
ocular blood flow;
age-related macular degeneration
- From:
International Eye Science
2009;9(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of naringenin on laser-induced experimental choroidal neovascularization (CNV) in rat models,ocular blood flow in rabbit eyes and retinal function recovery after ischemic insults in rat eyes.membrane. Naringenin 10g/L(20mg/kg) was given once-daily through intraperitoneal injection for 4 weeks after laser treatment. The development of CNV was determined by fluorescein angiography(FA) performed on weeks 2 and 4. The colored microsphere technique and electroretinography method were used for the study of ocular blood flow and retinal function recovery,respectively.RESULTS: The choroidal blood flow in elevated intraocular pressure (IOP) rabbit eyes was significantly increased by 10g/L naringenin solution as compared to control group(P<0.05) . The retinal function recovery after ischemic insults in rat eyes indicated significant increase of b-wave recovery in treated group,as compared to control group(P<0.05).The intensity of fluorescein leakage from the photocoagulated lesions decreased significantly in treated group,compared to the control group(75.8%-95.0%,P<0.01). CONCLUSION: Naringenin could prevent the development of CNV on laser-induced experimental rat models,increase the choroidal blood flow in elevated IOP rabbit eyes and be beneficial on retinal function recovery in ischemic rat eyes.
