Injection of tissue plasminogen activator into the optic nerve in an animal model of retinal vein occlusion
10.3969/j.issn.1672-5123.2009.06.003
- VernacularTitle:视盘内注射组织凝血酶原激活剂治疗视网膜中央静脉阻塞的初步研究
- Author:
Cai-Hui, JIANG
;
Mao-Nian, ZHANG
;
Motohiro KAMEI
- Publication Type:Journal Article
- Keywords:
central retinal vein occlusion;
tissue plasminogen activator;
intraoptic nerve injection;
throm-bolysis
- From:
International Eye Science
2009;9(6):1020-1025
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the feasibility and efficacy of tissue plasminogen activator (tPA) injection into the optic nerve as a treatment for retinal vein occlusion in rabbits. METHODS: Rose Bengal-mediated laser-induced retinal vein occlusions were produced in rabbit eyes. Fluorescein angiography (FA) was performed on each eye 3 days before laser irradiation and 30 minutes after laser irradiation.The treatment group (n=20 veins) received intra-optic nerve injection of tPA (12.5μg in 0.05mL BSS) and the controls (n=24 veins) received 0.05mL BSS. FA was repeated to determine the recanalization of the vessel at 3 and 7 days after treatment, followed by histological examination.RESULTS: Rose Bengal-mediated laser-induced retinal vein occlusions were successfully developed and confirmed by FA. The incidence of the recanalization of the vessels in treatment animals was 70.0%, while 16.7% in the control animals (P=0.001). CONCLUSION: Intra-optic nerve tPA injection increased the incidence of recanalization of the occluded vessels. Although further studies are needed, our data suggested that injection of tPA into the optic nerve may have a potential benefit in the treatment of central retinal vein occlusion.
