Recent advances on the modified endostatin and ocular neovascularization
10.3969/j.issn.1672-5123.2009.04.009
- VernacularTitle:改良内皮抑素与眼部新生血管的研究进展
- Author:
Hua, LI
;
Ping, LIU
;
Hong-Yan, GE
- Publication Type:Journal Article
- Keywords:
modified endostatin;
ocular neovasculari-zation;
antiangiogenesis activity
- From:
International Eye Science
2009;09(4):642-644
- CountryChina
- Language:Chinese
-
Abstract:
Endostatin(ES), the C-terminal fragment of collagen XVIII, is a potent angiogenesis inhibitor. At present, there are a large number of research papers on ES. It has already been on clinical stage Ⅱ and been widely used in inhibition of neovascularization(NV). However, how to improve the bioactivity of ES is still a matter of ongoing discussion. The objective of this review is to elucidate the relationship between the modified ES and ocular neovascualrization, and to discuss the superiority based on the structure modification. The structure can be changed either by covalent modification or by genetical mutation. It is proposed that the secondary structral ES enhance the anti-angiogenic activity. Studies on modified ES also shed light on our understanding of the molecular action mechanisms of ES. Modified ES may be exploited as a new angiogenesis inhibitor for therapeutic applica-tions, in substitution of the native ES. Activity
