Effect of pan-retinal laser photocoagulation on plasma VEGF endothelin-1 and nitric oxide in PDR
10.3969/j.issn.1672-5123.2009.10.001
- VernacularTitle:视网膜全光凝对糖尿病视网膜病变患者血浆VEGF,ET-1和NO的影响
- Author:
Mohamed Ahmed TAREK
;
Mohamed El-deek SAHAR
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
microangiopathy;
pan-retinal photocoagulation;
vascular endothelial growth factor;
endothelin-1;
nitric oxide
- From:
International Eye Science
2009;9(10):1843-1846
- CountryChina
- Language:Chinese
-
Abstract:
·AIM: To study plasma levels of vascular endothelial growth factor (VEGF), endothelin-1(ET-1) and nitric oxide (NO) in patients with proliferative diabetic retino-pathy (PDR) before and after pan-retinal photocoagula-tion (PRP).·METHODS: In this prospective study, forty patients (23 females and 17 males, mean age 48.5±12.2) with PDR without previous PRP therapy were studied. Blood samples were obtained before and 3 months after the last PRP session. Baseline (prelaser) plasma levels of VEGF, ET-1 and NO were compared with their levels in 30 healthy age- and sex- matched controls and also with plasma levels 3 months post-PRP. ·RESULTS: Patients with PDR had significantly raised plasma VEGF (375±89ng/L), ET-1(20±5ng/L) and NO (135±53μmol/L) when compared with healthy control group (P<0.01). After PRP, there was a significant re-duction in plasma VEGF (179±66ng/L), ET-1 (11±5ng/L) and NO (91±49μmol/L) levels at 3 months' follow-up but still significantly higher than healthy controls.·CONCLUSION: Patients with PDR demonstrate elevated VEGF, ET-1 and NO, which decreased after successful laser treatment.
