Treatment of blepharospasm with botulinum A toxin.

Author: Yoon Duck KIM ¹ ; Mark R. LEVINE
Author Information

1. Division of Ophthalmology, Eulji Hospital, Seoul, Korea.
Publication Type:Original Article ; Comparative Study
Keywords: essential blepharospasm; hemifacial spasm; botulinum A toxin
MeSH: Adult; Aged; Blepharospasm/*drug therapy; Botulinum Toxins/*therapeutic use; Eyelid Diseases/*drug therapy; Female; Humans; Male; Middle Aged; Time Factors
From:Korean Journal of Ophthalmology 1987;1(2):102-108
CountryRepublic of Korea
Language:English
Abstract: Thirty-nine patients with blepharospasm were treated with botulinum A toxin. Twenty-six patients had essential blepharospasm, and thirteen had a hemifacial spasm. A total of 113 injections were given, and the average follow-up was 14.6 months. The mean preinjection spasm intensity was 2.9+ and the mean postinjection spasm intensity was 0.7+. The mean interval between injections was 4.4 months. The treatment was effective, although transient, in all patients with essential blepharospasm and hemifacial spasm. The toxin had a prolonged effect on the patients who had previously undergone muscle stripping procedure. The side effects were mild, transient, and local.