Influence of topical anesthetics on oculocardiac reflex and corneal healing in rabbits
10.3969/j.issn.1672-5123.2009.12.001
- VernacularTitle:局部麻醉对兔眼心反射和眼角膜愈合的影响
- Author:
Jay, SINGH
;
Subhasis ROY
;
Prasenjit MUKHERJEE
;
Debajyoti KONAR
;
Aditya KONAR
;
Sarbani HAZRA
- Publication Type:Journal Article
- Keywords:
oculocardiac reflex;
topical anesthetics;
corneal healing;
ketamine;
propofol
- From:
International Eye Science
2009;9(12):2255-2259
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the incidence of oculocardiac reflex (OCR) with two anesthetic regimens and its prevention using topical anesthetics in a rabbit model. We also investigated the effect of topical anesthetics on corneal healing.METHODS: Forty-eight clinically healthy adult New Zealand white rabbits of either sex were divided into two groups (Group A and B) and anesthetized with either ketamine (Group A, n=24) or propofol (Group B, n=24). In this study , the incidence of OCR was recorded in each group with a variety of ocular manipulation with or without the use of topical anesthetics (40g/L lignocaine, 5g/L proparacain, 5g/L bupivacaine). Corneal toxicity and healing following the use of each topical anesthetic was assessed one day after surgery and up to 7 days postoperatively by clinical examination of the eye, histopathology and collagen staining and transmission electron microscopy.RESULTS: No incidence of OCR was recorded with ocular manipulation under ketamine anesthesia, whereas significant reduction in heart rate (P<0.01) was recorded under propofol anesthesia. Topical anesthetics could successfully prevent the OCR without affecting the corneal healing.CONCLUSION: Topical anesthetics may be recommended for prevention of OCR without any local adverse effect.
