An increased expression of CD40/CD40L costimulatory molecules in erythema nodosum of patients with Beh(c)et's disease
- VernacularTitle:Beh(c)et病患者结节红斑组织中CD40/CD40L共刺激分子的表达
- Author:
Hong, WANG
;
Pei-Zeng, YANG
;
Xiao-Yan, PENG
;
Meng, ZHAO
;
Hong-Yan, ZHOU
;
Xiang-Kun, HUANG
- Publication Type:Journal Article
- Keywords:
Beh(c)et's disease;
erythema nodosum;
costimulatory molecules
- From:
International Eye Science
2007;7(4):883-886
- CountryChina
- Language:Chinese
-
Abstract:
· AIM: To investigate the expression and the possible implication of CD40/CD40L costimulatory molecules in erythema nodosum of patients with Beh(c)et's disease.· METHODS: Sampling was done from erythema nodosum of 5 patients with Beh(c)et's disease and normal skin of 2 healthy individuals. Immunohistochemical staining was performed to examine the expression of CD4, CD8, CD19, CD68, HLA-DR,CD40 and CD40L molecules in the obtained tissues.· RESULTS: Approximately 90% of epidermic cells in erythema nodosum expressed CD40 molecule. In the dermis and subcutaneous tissue, a significantly increased number of CD4+Tcells, CD8+Tcells, CD19+cells, CD68+cells, HLA-DR+cells,CD40L+cells, and CD40+cells were observed in the erythema nodosum as compared with that in normal skin. Double staining showed that CD40L molecules were expressed on 45% of CD4+T cells. CD40 molecules were expressed on 100% CD68+ cells and 59.2% of HLA-DR+cells respectively.· CONCLUSION: A number of CD40/CD40L costimulatory molecules are upreguiated in the erythema nodosum of patients with Behcet's disease.
