Expression of Nogo-A on the retina in rat model with chronic ocular hypertension

VernacularTitle:大鼠慢性高眼压视网膜Nogo-A的表达
Author: Qing-Zhu, NIE ; Zhi-Li, LIU ; Qian, SHA ; Dian-Wen, GAO
Publication Type:Journal Article
Keywords: retina; chronic hypertension; Nogo-A; retinal retinal ganglion cell
From: International Eye Science 2010;10(5):825-826
CountryChina
Language:Chinese
Abstract: ·AIM: To study the expressive variation of Nogo-A on rat retina in the process of chronic ocular hypertension. · METHODS: Thirty-six healthy adult male Wistars were randomly divided into control group (6 rats) and chronic hypertension group (30 rats). Chronic hypertension was created by cauterizing the superficial scleral veins. Immunohistochemistry technique was used to evaluate the expressive varieties of Nogo-A at different time points during the course of chronic ocular hypertension. · RESULTS: The success of the model was indicated by over 40% of increase in the IOP as compared with normal rats. Compared with control group, as time passed chronic hypertension group gradually had detectable morphology changes in the retina. At the 21st day of chronic ocular hypertension, retinas became thinner and the quantity of retinal ganglion cell (RGC) decreased (P<0.05). Assoicated with the morphological changes, the expression of Nogo-A was strongly increased (P<0.05).CONCLUSION: Myelin associated protein Nogo-A plays a part in the process of chronic ocular hypertension.