Effect of flavone on the ocular blood flow and formation of choroidal neovascularization

VernacularTitle:黄酮对眼部血流量和脉络膜新生血管的作用
Author: Pei, ZHUANG ; Yi, SHEN ; George C Y CHIOU
Publication Type:Journal Article
Keywords: flavone; age-related macular degeneration; ocular blood flow; choroidal neovascularization
From: International Eye Science 2010;10(8):1455-1458
CountryChina
Language:Chinese
Abstract: AIM:To investigate the effect of flavone on ocular blood flow in rabbit eyes and the formation of choroidal neovascularization(CNV)in rat model of age-related macular degeneration(AMD).METHODS:In in vivo studies,colored microsphere technique was used to determine the ocular blood flow in ocular hypertensive rabbit eyes.The rat eyes were treated with 5g/L flavone eye drops 3 times a day for 1 week before and 4 weeks after laser-induced injury of Bruch's membrane.The development of CNV was determined by fluorescein angiography(FA)performed on weeks 2 and 4.In in vitro studies,the effect of flavone on the viability of HUVECs was measured by MTT assay.RESULTS:The ocular blood flow in rabbit eyes was significantly increased after flavone instillation.Flavone significantly inhibited the formation of laser induced CNV.In vitro resultsshowedthat fiavoneinhibited the proliferation of HUVECs.CONCLUSION:Flavone could increase ocular blood flow and inhibit the formation of CNV.