Optimized alloxan-induced diabetic rabbit model
10.3969/j.issn.1672-5123.2010.10.002
- VernacularTitle:改良四氧嘧啶制作兔糖尿病模型的实验研究
- Author:
Wen-Tao, SUN
;
Chun-Ling, LEI
;
Si-Hai, ZHAO
;
Chun-Chao, BI
;
Lu, ZHANG
- Publication Type:Journal Article
- Keywords:
alloxan;
diabetes;
rabbit;
death rate;
success rate
- From:
International Eye Science
2010;10(10):1848-1850
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the frequency of drug injection of alloxan diabetes on the established model of rabbit.METHODS: Thirty-six healthy rabbits, weighing 2-2.5kg, were randomly divided into one time drug injection group (group A, n=12), two times drug injection group (group B, n=12) and three times drug injection group (group C, n=12). Each rabbit was injected with a total amount of 150mg/kg of alloxan. Fasting blood glucose was measured. The success rate and death rate of each group were also calculated.RESULTS: The success rate of diabetic rabbit model in group B was higher than that in group A (P<0.01) and its death rate was lower than that of group A (P<0.01); the success rate of diabetic rabbit model in group C was highest and the death rate was the lowest in three groups(P<0.01). CONCLUSION: Multiple administration of alloxan can improve success rate in establishing diabetic rabbit model with decreased death rate and increased stability.
