Effect of ginsenoside-Rg3 on the expression of VEGF and TNF-α in retina with diabetic rats
10.3969/j.issn.1672-5123.2010.10.004
- VernacularTitle:人参皂甙Rg3对糖尿病大鼠视网膜VEGF和TNF-α表达的影响
- Author:
Hong-Quan, SUN
;
Zhan-Yu, ZHOU
- Publication Type:Journal Article
- Keywords:
ginsenoside-Rg3;
diabetic retinopathy;
vascular endothelial growth factor;
tumor necrosis factor-α
- From:
International Eye Science
2010;10(10):1855-1857
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of ginsenoside-Rg3 on the expression of vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) in retina with diabetic rats and its roles in preventing neovascularization in diabetes. METHODS: Sixty male Wistar rats were divided into 3 groups randomly: negative control group, diabetic control group and ginsenoside-Rg3 treatment group (5mg/kg, 0.2mg/mL) followed by establishing diabetic model. The expression of VEGF and TNF-α were measured after 8 weeks. RESULTS: There were significant differences among negative control group, diabetic control group and ginsenoside-Rg3 treatment group in the expression of VEGF and TNF-α (F=129.363, 211.992; all the P<0.01). VEGF and TNF-α expression were significantly higher in diabetic control group and ginsenoside-Rg3 treatment group than that in negative control group (P<0.01), with a significant reduction in ginsenoside-Rg3 treatment group than that in diabetic control group (P<0.01). CONCLUSION: Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina, which may interfere in the development of diabetic retinopathy.
