Long-term Treatment Outcomes for Autoimmune Hepatitis in Korea.
10.3346/jkms.2010.25.1.54
- Author:
Jae Sook KIL
1
;
Joon Hyoek LEE
;
A Reum HAN
;
Ja Young KANG
;
Hye Jin WON
;
Han Young JUNG
;
Hyun Min LIM
;
Geum Youn GWAK
;
Moon Seok CHOI
;
Kwang Cheol KOH
;
Seung Woon PAIK
;
Byung Chul YOO
Author Information
1. Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. liverjhlee@skku.edu
- Publication Type:Original Article
- Keywords:
Hepatitis, Autoimmune;
Immunosuppression;
Recurrence;
Survival
- MeSH:
Adolescent;
Adult;
Aged;
Azathioprine/therapeutic use;
Disease-Free Survival;
Drug Therapy, Combination;
Female;
Hepatitis, Autoimmune/*drug therapy/mortality/pathology;
Humans;
Immunosuppressive Agents/*therapeutic use;
Male;
Middle Aged;
Prednisolone/therapeutic use;
Prognosis;
Recurrence;
Republic of Korea;
Retrospective Studies;
Time Factors;
Treatment Outcome
- From:Journal of Korean Medical Science
2010;25(1):54-60
- CountryRepublic of Korea
- Language:English
-
Abstract:
Immunosuppressive therapy can improve clinical, biochemical and histological features and considerably prolong survival in patients with autoimmune hepatitis. Although ethnicity may affect disease severity and presentation, the long-term outcome of immunosuppression in Korean populations is unknown. This study was aimed to assess the efficacy of immunosuppressive therapy and determine the prognosis of autoimmune hepatitis in Korean populations. We reviewed the medical records of 86 patients diagnosed as having autoimmune hepatitis at the Samsung Medical Center between 1994 and 2008. Seventy-two (83.7%) patients reached remission after a median treatment duration of 3.5 months (range 1 to 44 months). Attempts to withdraw medications were made in 24 cases after the median treatment duration of 36 months (median 6 to 125 months). Thirteen of 24 (54.1%) patients relapsed after treatment withdrawal. Of the 86 patients, 6 (7.2%) experienced disease progression and the overall 5-and 10-yr progression-free survival rates were 91.2% and 85.5%, respectively. In conclusion, immunosuppressive therapy for autoimmune hepatitis results in a favorable rate of remission and excellent progression-free survival, but the relapse rate after treatment withdrawal is high. This suggests that long-term immunosuppressive therapy may be particularly important for treatment of Korean patients.
