Usefulness of Non-invasive Markers for Predicting Significant Fibrosis in Patients with Chronic Liver Disease.
10.3346/jkms.2010.25.1.67
- Author:
Han Hyo LEE
1
;
Yeon Seok SEO
;
Soon Ho UM
;
Nam Hee WON
;
Hanna YOO
;
Eun Suk JUNG
;
Yong Dae KWON
;
Sanghoon PARK
;
Bora KEUM
;
Yong Sik KIM
;
Hyung Joon YIM
;
Yoon Tae JEEN
;
Hoon Jai CHUN
;
Chang Duck KIM
;
Ho Sang RYU
Author Information
1. Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. umsh@korea.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Liver Cirrhosis;
Biological Markers;
Chronic Liver Disease
- MeSH:
Adult;
Biological Markers/blood;
Chronic Disease;
Fatty Liver/complications;
Female;
Fibrosis;
Haptoglobins/analysis;
Hepatitis B/complications;
Hepatitis C/complications;
Humans;
Hyaluronic Acid/blood;
Liver Cirrhosis/complications/*diagnosis;
Liver Diseases/complications/*diagnosis;
Male;
Middle Aged;
Predictive Value of Tests;
Prospective Studies;
ROC Curve;
alpha-Macroglobulins/analysis
- From:Journal of Korean Medical Science
2010;25(1):67-74
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as > or =F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, alpha2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, alpha2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.
