Nutritional Status of Vitamin D and the Effect of Vitamin D Supplementation in Korean Breast-fed Infants.
10.3346/jkms.2010.25.1.83
- Author:
Mi Jung KIM
1
;
Bomi NA
;
So Jung NO
;
Heon Seok HAN
;
Eun Hwan JEONG
;
Wonkuk LEE
;
Younghee HAN
;
Taisun HYEUN
Author Information
1. Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Korea. mijung0412@chungbuk.ac.kr
- Publication Type:Original Article ; Controlled Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Vitamin D;
Nutritional Status;
Bone Density;
Vitamin D Deficiency;
Dietary Supplements;
Breast feeding;
Infant
- MeSH:
Alkaline Phosphatase/blood;
Bone Density;
*Breast Feeding;
Calcifediol/*blood;
Calcium/blood;
Cholecalciferol/blood;
*Dietary Supplements;
Female;
Humans;
Infant, Newborn;
Male;
Parathyroid Hormone/blood;
Phosphorus/blood;
Questionnaires;
Republic of Korea;
Vitamin D/*administration & dosage
- From:Journal of Korean Medical Science
2010;25(1):83-89
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the vitamin D status and the effect of vitamin D supplementation in Korean breast-fed infants. The healthy term newborns were divided into 3 groups; A, formula-fed; B, breast-fed only; S, breast-fed with vitamin D supplementation. We measured serum concentrations of vitamin D (25OHD3), calcium (Ca), phosphorus (P), alkaline phosphatase (AP), intact parathyroid hormone (iPTH) and bone mineral density (BMD) at 6 and 12 months of age. Using questionnaires, average duration of sun-light exposure and dietary intake of vitamin D, Ca and P were obtained. At 6 and 12 months of age, 25OHD3 was significantly higher in group S than in group B (P<0.001). iPTH was significantly lower in group S than in group B at 6 months (P=0.001), but did not differ at 12 months. Regardless of vitamin D supplementation, BMD was lower in group B and S than in group A (P<0.05). Total intake of vitamin D differed among 3 groups (P<0.001, A>S>B), but total intake of Ca and P were higher in group A than in group B and S (P<0.001). In conclusion, breast-fed infants show lower vitamin D status and bone mineralization than formula-fed infants. Vitamin D supplementation (200 IU/day) in breast-fed infants increases serum 25-OH vitamin D3, but not bone mineral density.
