Influence of paraquat on oxidative stress of dopaminergic neuron in substantia nigra of mice
- VernacularTitle:百草枯对小鼠黑质多巴胺能神经元氧化应激的影响
- Author:
jin-peng, REN
;
xiao-jiang, SUN
;
yu-ping, JIANG
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
paraquat;
oxidative stress
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the oxidative stress pathogenesis of Parkinson's disease(PD) induced by paraquat in substantia nigra of mice. Methods The model of PD was established by oral administration of paraquat to mice.The spectrophotometry was used to determine the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) and the content of malondialdehyde(MDA) in substantia nigra.At the same time,number of tyrosine hydroxylase(TH) positive neurons in substantia nigra of mice was estimated by immunohistochemistry. Results The activities of SOD and GSH-PX were significantly decreased,and the content of MDA was increased in paraquat-treated mice compared to that of mice treated by saline taken orally(P
