Clinical study on human lamellar keratoplasty for fungal corneal ulcers with porcine acellular corneal stroma
10.3980/j.issn.1672-5123.2017.9.37
- VernacularTitle:使用猪角膜脱细胞基质的人板层角膜移植治疗真菌性角膜炎的临床观察
- Author:
Fu-Hong, LIAO
;
Zi-Zhong, YU
;
Bin, HU
- Keywords:
porcine acellular corneal stroma;
corneal transplantation;
fungal corneal
- From:
International Eye Science
2017;17(9):1750-1752
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the transplantation of acellular porcine corneal stroma on the treatment of superficial keratitis by drug-resistant fungal.METHODS:We performed a retrospective analysis of 16 cases of fungal keratitis received the transplantation of acellular porcine corneal matrix from June 2015 to March 2016 with a follow-up of 6mo.We analyzed on items as postoperative visual acuity, corneal graft status, postoperative recurrence and postoperative complications.RESULTS:We observed a healing time of corneal epithelium in 7 to 10d postoperatively generally and the absence of corneal edema in 1mo, while the cornea gradually returned transparent in the 16 cases.Two cases required medication for an epithelial recovery and 3 cases received intervention for decreasing intraocular pressure to a certain level.During the follow-up we observed no cases of cornea degeneration, recurrence of infection or rejection.The vision acuity showed 1.27±0.22, 1.11±0.13, 0.79±0.22 in 1, 3 and 6mo after operation respectively.There was no statistical difference between vision in 1mo and the vision before surgery (P=0.06);while we found a statistical difference when comparing the vision of 3 and 6mo with vision before surgery (P=0.01,0.001).The vision in 6mo increased with a statistic difference to the vision at 1 and 3mo (P<0.001) while no statistic difference was observed between 1 and 3mo(P=0.11).CONCLUSION:Transplantation of acellular porcine corneal matrix is a safe and efficient treatment for fungal keratitis.
