Current researches of function and mechanism of peroxisome proliferator-activated receptor-γ in diabetic retinopathy
10.3760/cma.j.issn.2095-0160.2017.07.016
- VernacularTitle:过氧化物酶体增生物激活受体γ在糖尿病视网膜病变中的作用及机制研究进展
- Author:
Tao, LI
- Keywords:
Peroxisome proliferator-activated receptor-γ;
Diabetic retinopathy;
Function;
Mechanism
- From:
Chinese Journal of Experimental Ophthalmology
2017;35(7):651-654
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator-activated receptor gamma (PPAR-γ),a member of the nuclear receptor superfamily,plays a great role in delaying or even preventing the occurrence and/or development of diabetic retinopathy (DR),a complicated out-of-control waterfall-like pathophysiological processes.DR is characterized by pathways,such as inflammatory reactions,the generation of advanced glycation end products,oxidative stress,protein kinase C and so on.As one of the most important metabolic homeostasis and adipocyte differentiation regulator,the single nucleotide polymorphism and molecular structure of PPAR-γ have been proven to impact on anti-inflammation,anti-neovascularization and fibration,antioxidation,insulin sensitizer and anti-apoptosis in DR.This review provided a summary of the function and mechanism researches on PPAR-γand offered new ideas of prevention and therapy in DR.
