Gene research progress of retinoblastoma
10.3760/cma.j.issn.2095-0160.2017.08.019
- VernacularTitle:视网膜母细胞瘤相关基因研究进展
- Author:
Tian, YU
- Keywords:
Retinoblastoma;
RBI;
MYCN;
Gene
- From:
Chinese Journal of Experimental Ophthalmology
2017;35(8):756-760
- CountryChina
- Language:Chinese
-
Abstract:
Retinoblastoma (RB) is a common intraocular malignant tumor of infants.It not only seriously threats children's eyesight,but also endangers their lives.RB develops from the immature cells of retina and its occurrence is closely related with the tumor suppressor gene RB1.The inactivation of two alleles of RB1 is the basis of RB occurrence and development.With the rapid development of biological technology,RB gene related research has made great progress.Researches showed that there are many changes in the chromosome level of RB.Many genes are also involved in the development and progression of RB,including oncogene MYCN,murine double minute 4 (MDM4,also known as MDMX),driver protein family members 14 (K IF14),DEK,E2F3,tumor suppressor gene calcium 11 (CDH11) and so on.This review summarizes the progress in gene research of RB,reveal pathogenesis of RB on DNA molecular level and provides a scientific basis for clinical doctors to formulate effective therapeutic plans.
