Advancement of endostatin on inhibiting neoangiogenesis of diabetic retinopathy
10.3760/cma.j.issn.2095-0160.2017.05.018
- VernacularTitle:内皮抑素抑制糖尿病视网膜新生血管生成中的研究进展
- Author:
Ming, ZHANG
- Keywords:
Endostatin;
Diabetic retinopathy;
Ocular neovascularization;
Vascular endothelial growth factor
- From:
Chinese Journal of Experimental Ophthalmology
2017;35(5):474-477
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is a common disease of ophthalmology,often causes irreversible decline of patients' vision,which has two features including macular oedema,diabetic retinal neovascularization.Diabetic retinal neovascularization is one of the most important reasons leading to blindness.Endostatin (ES) is one of the most effective agents inhibiting angiogenesis,whose biological function has a close relationship with its chemical construction.However,its mechanisms of treating diabetic retinal neovascularization are very complicated and remain unclear.Therefore,in this review we summarized several possible mechanisms,including regulating the expression of extracellular matrix,inhibiting the expression of pro-angiogenic factors,and regulating the signaling pathways,by which ES may inhibiting diabetic retinal neovascularization.
