Role of long non - coding RNA in the pathogenesis of diabetic retinopathy
10.3980/j.issn.1672-5123.2017.10.12
- VernacularTitle:长链非编码RNA在糖尿病视网膜病变中的作用
- Author:
Xiu-Juan, YUE
;
Sheng, SU
;
Ping, LIU
- Keywords:
long non-coding RNA;
diabetic retinopathy;
gene regulation
- From:
International Eye Science
2017;17(10):1852-1855
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA ( LncRNA) is a class of transcript (>200 nucleotides) that do not encode proteins. It plays an important role in epigenetic regulation and gene expression at transcriptional or post transcriptional level. The abnormal expression of LncRNA may lead to various pathological processes. Diabetic retinopathy ( DR ) is a multifactorial disease. Recent studies have shown that many specific expressions of LncRNAs are closely related to the genesis of DR. In this review, we summarized the recent advances in the function of LncRNA, the regulatory mechanisms of LncRNA involved in the development of DR, and the related therapies.
