Acute Lymphoblastic Leukemia Manifesting as Acute Vogt-Koyanagi-Harada Disease.
10.3341/kjo.2009.23.4.325
- Author:
Hee Kyung YANG
1
;
Hyeong Gon YU
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea. hgonyu@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Exudative retinal detachment;
Leukemia;
Vogt-Koyanagi-Harada disease
- MeSH:
Adult;
Diagnosis, Differential;
Fluorescein Angiography;
Follow-Up Studies;
Fundus Oculi;
Humans;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/*diagnosis;
Retinal Detachment/diagnosis/*etiology;
Tomography, Optical Coherence;
Uveomeningoencephalitic Syndrome/*diagnosis;
Visual Acuity
- From:Korean Journal of Ophthalmology
2009;23(4):325-328
- CountryRepublic of Korea
- Language:English
-
Abstract:
We describe a case of bilateral exudative retinal detachment associated with prodromal symptoms simulating the presentation of acute Vogt-Koyanagi-Harada disease that was eventually diagnosed as acute lymphoblastic leukemia. A 42-year-old man presented with sudden visual loss in both eyes for two weeks. He complained of intermittent headache, neck stiffness and tinnitus for a month. His best-corrected visual acuities were 20/200 in both eyes. Fluorescein angiography, optical coherence topography and indocyanine green angiography featured bilateral serous retinal detachments. A clinical diagnosis of incomplete type Vogt-Koyanagi-Harada disease was considered. However, complete blood cell count showed a marked increase in the number of white blood cells and bone marrow examination revealed precursor B cell lymphoblastic leukemia. The patient started on induction chemotherapy. A week later, his best-corrected visual acuities were 20/25 and the serous retinal detachments were nearly absorbed in both eyes. Bilateral exudative retinal detachment associated with neurologic and auditory abnormalities may be a presenting sign of acute lymphoblastic leukemia. Clinicians should be aware of the possibility of leukemia in such patients.
